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fool
03:00 Sat 30
Sanofi Stops Supplying Hydroxychloroquine to COVID-19 Patients in Clinical Trials
The malaria drug is quickly falling out of favor with the medical community as a potential treatment for the disease.

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microbe tv
14:39 Sat 28
Nws
TWiV 686: COVID-19 clinical update #38 with Dr. Daniel Griffin
Daniel Griffin provides his weekly clinical report on COVID-19, including new post-exposure guidelines from CDC, clinical trials of Remdesivir and convalescent plasma, FDA EUA for baricitinib and Regeneron's monoclonal antibody and more. The post TWiV 686: COVID-19 clinical update #38 with Dr. Daniel Griffin first appeared on This Week in Virology .

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physiciansweekly
09:30 Thu 26
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Covid-19: HydroxychloroquineNope, Still Not a Viable Treatment
This time it fails as a prophylaxis Yet another study fails to find a place for hydroxychloroquine in the treatment of Covid-19, this time as postexposure prophylaxis or preemptive therapy. In a cluster-randomized trial, patients assigned to receive hydroxychloroquine were not protected against SARS-CoV-2 infection or symptomatic Covid-19 any better than those assigned usual care […]

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physiciansweekly
09:32 Fri 27
Nws
Covid-19: HydroxychloroquineNope, Still Not a Viable Treatment
This time it fails as a prophylaxis Yet another study fails to find a place for hydroxychloroquine in the treatment of Covid-19, this time as postexposure prophylaxis or preemptive therapy. In a cluster-randomized trial, patients assigned to receive hydroxychloroquine were not protected against SARS-CoV-2 infection or symptomatic Covid-19 any better than those assigned usual care […]

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siliconrepublic
11:24 Fri 27
Nws
Advarra acquires Irish firm Longboat to enhance clinical trials
Dublin-based tech company Longboat will join Advarra with the aim of making clinical trials safer and more efficient. The post Advarra acquires Irish firm Longboat to enhance clinical trials appeared first on Silicon Republic .

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news-medical net
02:35 Thu 26
Nws
Lungs of COVID-19 patients show good recovery in most cases
Lung tissue of patients who suffered severely from COVID-19 shows good recovery in most cases. This was revealed by a study carried out by the Radboud university medical center that has now been published in Clinical Infectious Diseases.

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feedburner
00:43 Thu 26
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A Clinical Trials Expert Explains Why We Should Feel Optimistic About COVID Vaccines
'It has been a triumph of medical science.'

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@ABSCBNNews
23:54 Fri 27
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Clinical trials of 2 Chinese COVID-19 vaccines may start yearend or early 2021 DOST https://t.co/2oM5rFCWyy
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prnewswire:443
23:28 Sat 28
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Colchicine shows promise as a treatment for at-home COVID-19 patients -- Recruitment of participants in the COLCORONA phase 3 study likely to end in 2020
MONTREAL, Nov. 28, 2020 /PRNewswire/ -- The Montreal Heart Institute (MHI) today announced that the COLCORONA clinical trial will continue to recruit non-hospitalized adult patients with COVID-19 as recommended by the independent data monitoring committee (DMC), following a second interim...

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@the_hindu
09:40 Fri 27
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Bharat Biotech is developing COVID-19 vaccine #Covaxin in collaboration with the #ICMR. Phase III clinical trials o https://t.co/Aiwf2qfPMN
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@ABSCBNNews
15:49 Fri 27
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PH might start COVID-19 vaccine clinical trials with 2 Chinese vaccine developers by end of 2020 or start of next https://t.co/wHeoCpLiKI
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forbes
16:54 Fri 27
Nws
How Effective Will Covid-19 Coronavirus Vaccines Be? 8 Reasons Its Too Early To Tell
Since November 9, three vaccine manufacturers, Pfizer, followed by Moderna and then AstraZeneca, have offered some preliminary results from their Phase 3 clinical trials.

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healthtechmagazine net
17:22 Wed 25
How to Set Up Healthcare Mobility Solutions for Long-Term Success
For most healthcare organizations, the decision to deploy clinical mobility technology is driven by a need for optimized team communications. Evolving circumstances and requirements can inform efforts intended to re-evaluate clinical workflows and supporting tools. COVID-19 has underscored these challenges and demonstrated the high value mobile devices can bring to providers and patients. Clinical mobility solutions represent the convergence of communication and collaboration tools on a single device; however, video capabilities are not always included in the standard solution set.

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feedburner
21:00 Wed 25
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Dexamethasone May Be Detrimental to Immunotherapy in Glioblastoma Patients
Historically, patients with glioblastoma have been empirically treated with dexamethasone, even without symptoms, with many clinicians prescribing steroids for prolonged periods of time, out of a concern that patients may start to develop edema. Preclinical and clinical data indicate that concurrent dexamethasone therapy may be detrimental to immunotherapeutic approaches for patients with glioblastoma (GBM). The post Dexamethasone May Be Detrimental to Immunotherapy in Glioblastoma Patients appeared first on GEN - Genetic Engineering and Biotechnology News .

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modernhealthcare
20:02 Wed 25
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Arizona stops some transfers of patients from other states
Out-of-state hospitals can still transfer patients into Arizona through direct hospital-to-hospital requests, but the use of the interstate Arizona Surge Line system has been suspended.

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physiciansweekly
05:20 Thu 26
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Human papillomavirus genotype distribution in head and neck cancer: Informing developing strategies for cancer prevention, diagnosis, treatment and surveillance.
Current clinical practice algorithms for HPV testing make no effort to discern the impact of genotypes for patients with head and neck squamous cell carcinoma (HNSC). Data was collected for all patients with HNSCs that had undergone HPV testing at an academic hospital as part of clinical care (2012-2019). Screening was performed using real-time PCR […]

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businesstoday in
16:52 Fri 27
Nws
COVID-19 vaccine: What is emergency authorisation and why it is not for the masses?
After the publication of early data from phase-3 clinical trials, drugmakers Pfizer and BioNTech have sought regulatory approval to deploy their inoculation under emergency-use rules. American biotech company Moderna is also likely to do the same soon

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@ABSCBNNews
04:36 Fri 27
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@kristinesabillo Montoya: ASTRA Zeneca will still continue the clinical trials in PH to see whether we also have as https://t.co/XRonMY70WU
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@timesofindia
02:38 Fri 27
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India to consider clinical trials data of two full doses of AstraZeneca vaccine https://t.co/BciQerIf2D
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pharmaphorum
16:33 Thu 26
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Langland appoints Angela Rochelle to clinical trial diversity role
Langland has announced the appointment of Angela Rochelle as account director, head of diversity initiatives in clinical trials. The post Langland appoints Angela Rochelle to clinical trial diversity role appeared first on .

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@ABSCBNNews
06:12 Fri 27
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Vergeire on questions raised about AstraZeneca's #COVID19 vaccine clinical trials | via @kristinesabillo https://t.co/P3kjRsEqVP
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news google au
18:57 Wed 25
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Study Casts Doubt on Plasma as COVID Treatment - WebMD
Study Casts Doubt on Plasma as COVID Treatment    WebMD A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia    nejm.org No benefit seen from plasma treatment in severe COVID-19; virus may hurt male fertility    Reuters Studies find no COVID benefit for preventive hydroxychloroquine or for convalescent plasma    CIDRAP Plasma from recovered patients shows little benefit in those hospitalised with COVID-19: Study    Gulf News View Full coverage on Google News
WBMD
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news google au
17:59 Wed 25
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Another Study Casts Doubt on 'Convalescent Plasma' as COVID-19 Treatment - MedicineNet
Another Study Casts Doubt on 'Convalescent Plasma' as COVID-19 Treatment    MedicineNet A Randomized Trial of Convalescent Plasma in Covid-19 Severe Pneumonia    nejm.org Studies find no COVID benefit for preventive hydroxychloroquine or for convalescent plasma    CIDRAP No benefit seen from plasma treatment in severe COVID-19; virus may hurt male fertility    Reuters Plasma from recovered patients shows little benefit in those hospitalised with COVID-19: Study    Gulf News View Full coverage on Google News

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businesstoday in
15:33 Fri 27
NwsGlbl
Hetero Drugs to manufacture 100 million doses of Russian COVID-19 vaccine
The vaccine supplies for the global market will be produced by RDIF's international partners in India, Brazil, China, South Korea and other countries. The safety of vaccines based on human adenoviruses has been confirmed in more than 75 international publications and in more than 250 clinical trials.

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americanbankingnews
14:49 Sat 28
NwsOffrn
Skandinaviska Enskilda Banken AB publ Has $2.88 Million Holdings in Sanofi (NYSE:SNY)
Skandinaviska Enskilda Banken AB publ lessened its holdings in Sanofi (NYSE:SNY) by 3.9% during the 3rd quarter, according to its most recent filing with the Securities and Exchange Commission (SEC). The firm owned 57,400 shares of the company’s stock after selling 2,300 shares during the quarter. Skandinaviska Enskilda Banken AB publ’s holdings in Sanofi were […]

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itsecurityguru org
10:36 Fri 27
Nws
Personal data of 16 million COVID-19 patients in Brazil leaked online
The personal and health data of over 16 million Brazilian COVID-19 patients has been exposed after a hospital employee foolishly uploaded a spreadsheet or names, passwords, and access keys to sensetive government systems on GitHub. Two government databases, E-SUS-VE and Sivep-Gripe, used to store patients COVID-19 data, were among the systems exposed. The Sivep-Gripe database […] The post Personal data of 16 million COVID-19 patients in Brazil leaked online appeared first on IT Security Guru .

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news-medical net
16:53 Thu 26
Antihypertensive drugs may reduce COVID-19 mortality in at-risk patients
A new multicenter study that recently appeared on the medRxiv* preprint server in November 2020 has found a lower or equal risk of fatal COVID-19 in hypertensive patients, depending on the type of medication they are on.

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proactiveinvestors au
01:36 Wed 25
Emyria launches drug development program focused on mental health based on real-world evidence analysis
Emyria Limited (ASX:EMD) has launched its initial drug development program focused on mental health following deep analysis of its real-world evidence (RWE) generated from more than 3,000 patients.  The first end-to-end drug development program will encompass a package of clinical evidence, intellectual property (IP) and strategically developed clinical trial protocols.  This program is designed to support the registration of a specific cannabinoid-based medicine for a specific mental health indication with the Therapeutic Goods Administrations (TGA) Australian Register of Therapeutic Goods (ARTG).  Multiple, unique opportunities Emyria managing director Dr Michael Winlo, said: Were very enthusiastic about the launch of our own evidence-based drug development program after an extensive review of the IP landscape, published literature and, of course, our own clinical evidence. This work has identified multiple, unique opportunities to develop treatments for specific mental health concerns as well as novel IP, which we have protected. We are also well placed to rapidly register these treatments, given the unparalleled access we have to large patient populations across our independent clinical network, the clinical-trial grade data systems and remote monitoring technologies we have developed and our in-house expertise in data analysis, clinical trial design and drug registration. We expect this initial program to increase the availability of registered drug options for patients with mental health concerns and develop significant shareholder return in a highly capital-efficient manner. Growing global health concern Mental health is a growing global health concern affecting many of our current patients and this drug development program complements our recent partnership with Mind Medicine Australia focusing on the development of new treatment options for patients with major mental health concerns. We look forward to updating the market with our progress towards registration and commercialisation of this program while we support our current partners to advance their own registration programs. Significant market opportunity Currently, most medicinal cannabis products available in Australia are 'unapproved therapeutic goods', which means they have not been assessed by the TGA for quality, safety or effectiveness. Most of these products, therefore, can only be accessed via Special Access Schemes (SAS) or from Authorised Prescribers. A successfully registered treatment would be accessible to patients via routine prescription or, if the TGA allows, over-the-counter pathways, representing a significant potential market opportunity. Data analysis A decision to launch the program was made following a deep, longitudinal analysis of Emyrias extensive RWE data assets, which have been co-developed with patients treated by its Emerald Clinics service. The analysis revealed statistically significant dose-response data in a target patient population using a series of globally validated mental health measures. These data insights effectively replace the need for exploratory therapeutic clinical trials, and provide quality safety and efficacy data that will allow registration trials to be accelerated as the effective dose range and target patient population has now been identified from the aggregated patient usage data. On average, over 150 data points are collected per visit from each patient. Patients in the cohort analysis were regularly administered the DASS-21 (Depression Anxiety, Stress Scale - 21 elements) - a quantitative measure of distress. Data generated from the study analysis showed highly statistically significant improvements in the anxiety component of patients DASS-21 scores (P<0.001) when treated with selected doses of cannabidiol. This is particularly pertinent in the sub-population treated, all of which were not able to improve their anxiety measures using standard-of-care treatments prior to their referral to Emerald Clinics. The patient cohort was separately monitored for changes in average Brief Pain Inventory (BPI) scores - a self-reported assessment, which provides information on the intensity of pain and the degree to which pain interferes with ones function. Data generated from the study analysis showed highly statistically significant improvements in patients BPI scores (p < 0.001) when treated with selected doses of cannabidiol in the target cohort of patients. For a large proportion of patients treated, chronic pain had been a primary complaint lasting more than 5 years.

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skynews
15:33 Thu 26
Mrkts
Pair suspected of supplying inflatable boats to people smugglers arrested in Sussex
Investigators have arrested two suspects thought to be involved in supplying inflatable boats to people smugglers.

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@Newsweek
23:26 Fri 27
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Hydroxychloroquine for COVID treatment linked to suicidal behavior by European regulators https://t.co/1O6yNBUdrL
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druggist online
13:30 Fri 27
Clascoterone NEW cream for ACNE
This year, clascoterone (brand name: Winlevi) has been approved by The United States Food and Drug Administration (FDA) for treatment of acne in the US. In the UK, there are several options for the management of acne, including topical preparations and oral antibiotics. In this post, I will review clascoterone and compare it to other treatments available in the UK. I will also talk about any possibility of clascoterone cream reaching the UK. What is clascoterone? Clascoterone cream (Winlevi) is a new prescription-only cream for the treatment of acne approved in the US at the end of August 2020. Winlevi comes in the form of cream, which is applied twice a day. Age restrictions In the US, clascoterone is restricted to the treatment of acne in patients 12 years and over. Is clascoterone effective in the treatment of acne? The approval decision for drug licensing comes from information gathered during clinical trials. The primary evidence comes from the clinical trial involving 1440 patients with acne vulgaris. Patient applied either clascoterone (Winlevi) twice a day for 12 weeks or cream, which did not contain any active ingredients (patients not aware which treatment they were given). At the end of the 12-week trial, the treatment was successful in 18.4% and 20.3% (different age groups). Clascoterone: possible side effects Like with many other topical creams and gel for the treatment of acne, clascoterone can cause local irritation of the skin itching, redness, dryness and scaling, all of which are reported as a common side effect associated with the treatment. Overall, the side effects experienced by patients were mild and similar to patients who used a ‘dummy’ cream. How does clascoterone work to stop acne? Clascoterone cream is androgen receptor inhibitor. What does it mean? Androgens are a class of male ‘sex’ hormones, which contribute to the development of acne symptoms. Two androgens testosterone (T) and dihydrotestosterone (DHT) are produced in the skin and attach (bind) to receptors (Zouboulis, 2004) and consequently stimulate sebaceous glands to produce sebum, an oily substance. Sebum’s role is to lubricate the hair and skin. Overproduction of sebum can lead to blockage of hair follicles, to which sebaceous glands are connected to. Consequently, a plug is formed in the follicle, which causes symptoms of acne blackheads or whiteheads. Children get symptoms of acne during puberty as testosterone production rises during this time. Clascoterone stops the ‘attachment’ of hormones to the receptor found in the skin and therefore reduce the production of sebum. What are the acne treatment options in the UK? Broadly speaking, acne is treated with topical products (gels, creams, and lotions) and oral antibiotics. Mild to moderate acne is usually managed with skin products. Topical products for the treatment of acne may contain the following drugs: benzoyl peroxide, which is also available over the counter, without a prescription (brand name: Acnecide) retinoid alone or in combination with benzoyl peroxide or an antibiotic Topical antibiotic, which should always be prescribed in combination with another active ingredient, for example, benzoyl peroxide (see Duac Once Daily gel for acne). Addition of second active ingredient, such as benzoyl peroxide reduces the risk of bacterial resistance, which makes antibiotics less effective in the treatment of infectious conditions. Patients who fail to respond to topical treatment may be recommended to take andadditional oral antibiotics. Treatment of acne with oral antibiotic is usually limited to a maximum of 3 months. Optionally, some women may be offered an oral contraceptive for the treatment of acne, such as Dianette. New cream for acne – how does it differ from other topical treatments for acne? None of the drugs listed above affects hormones which contribute to acne symptoms. The mainstream treatment of acne in the UK is the use of combination skin products and oral antibiotics. Clascoterone offers a new approach to the treatment of acne. Can you get clascoterone cream in the UK? The approval of clascoterone (Winlevi) for the treatment of acne applies only to the US. Pharmaceutical companies need to apply for a separate license to the European Medicines Agency (EMA) if they wish to market their drug in Europe. At the moment clascoterone is not listed by EMA undermedicines which are under evaluation. Clascoterone for hair loss The company which developed clascoterone for the treatment of acne, Cassiopea, is in the process of trialling clascoterone solution 7.5% for the treatment of hair loss (androgenetic alopecia/AGA). The principle behind the treatment of hair loss has a similar mechanism to one of acne. Reduced effect of dihydrotestosterone (DHT) minimises thinning and shortening of a hair growth cycle and therefore helps to prevent baldness. Phase III clinical trials involving clascoterone solution 7.5% for the treatment of hair loss has not started yet. Conclusion Clascoterone cream is a novel, first in the class treatment of acne. It offers a new approach to acne treatment, which is favourable since clascoterone cream does not contain antibiotics. It would be reasonable to expect post-launch information on the effectiveness of clascoterone cream from a larger population of patients. Although clascoterone cream is not available in the UK or Europe, it would be a great addition to drugs used in the treatment of acne. References Zouboulis CC. Acne and sebaceous gland function. Clin Dermatol. 2004;22(5):360366. doi:10.1016/j.clindermatol.2004.03.004 Available at https://doi.org/10.1016/j.clindermatol.2004.03.004 Accessed on 26/11/2020   The post Clascoterone NEW cream for ACNE appeared first on Druggist.Online .

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cnbc
03:22 Sat 28
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Oxford, WHO scientists say more data needed on AstraZeneca's Covid vaccine trials
More data is needed from AstraZeneca's Covid vaccine trials beyond what was presented in a press release, experts from the WHO and Oxford University said.

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news google
23:43 Wed 25
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As Hospitals Strain Under Influx Of COVID-19 Patients, Deaths Are Climbing : Shots - Health News - NPR
As Hospitals Strain Under Influx Of COVID-19 Patients, Deaths Are Climbing : Shots - Health News    NPR Washington health officials address surge in COVID-19 hospitalization    KING5.com Man recounts fighting COVID-19 at Baltimore hospital    WBAL-TV 11 Baltimore Antibody Drugs For COVID-19 Finally Make It To Patients : Shots - Health News    NPR Health Care Workers On The Front Lines    WRTV Indianapolis View Full Coverage on Google News

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europeanpharmaceuticalreview
12:44 Thu 26
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Trial to compare dexamethasone and baricitinib in hospitalised COVID-19 patients
The fourth iteration of the COVID-19 treatment trial will determine whether remdesivir plus baricitinib or dexamethasone, is more effective at promoting recovery from COVID-19. The post Trial to compare dexamethasone and baricitinib in hospitalised COVID-19 patients appeared first on European Pharmaceutical Review .

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news-medical net
04:43 Thu 26
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Early use of existing treatment helps save hospitalized COVID-19 patients
The lives of patients hospitalized with COVID-19 are being saved by doctors who are using an existing medical treatment at an earlier stage.

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@zerohedge
13:41 Fri 27
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*U.K. COVID OUTBREAK STOPS SPREADING EXPONENTIALLY: ESTIMATE
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virology ws
16:07 Fri 27
TWiV 684: Persistence of SARS-CoV-2 immune memory
Daniel Griffin provides a clinical report on COVID-19, and Shane Crotty explains a study of antibodies, B cells and T cells in patients which suggests that immunological memory to SARS-CoV-2 might be long-lived. Click arrow to playDownload TWiV 684 (110 MB .mp3, 184 min)Subscribe (free): iTunes, Google Podcasts, RSS, email Show notes at microbe.tv/twiv

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sciencedaily
14:15 Wed 25
Research shows bariatric surgery may reduce severity of COVID-19 in patients with obesity
A new study shows that among patients who have obesity and who tested positive for COVID-19, a past history of bariatric surgery was significantly associated with a lower risk of hospital and intensive care unit admission.

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@guardian
15:41 Fri 27
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'The buck stops with her': June Raine to make call on UK's Covid vaccines https://t.co/bDIopy3DAD
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securityaffairs co
10:09 Fri 27
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Details of 16 million Brazilian COVID-19 patients exposed online
The personal and health details of more than 16 million BrazilianCOVID-19patients, including Government representatives, have been exposed online. Personal and health details of more than 16 million Brazilian COVID-19 patients has been accidentally exposed online due to an error of an employee of a Brazilian hospital. An employee of Albert Einstein Hospital in Sao Paolo […] The post Details of 16 million Brazilian COVID-19 patients exposed online appeared first on Security Affairs .

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feedburner
10:26 Thu 26
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Oramed Pharmaceuticals Advancing With an Oral Insulin
Oramed has screened the first patients in its global Phase 3 trials of its oral insulin capsule for... ... Continue reading
ORMP
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